![]() ![]() We found an improvement in BMI SDS in the SO-treated group compared to untreated patients, and this trend persisted also at 36 months of follow-up (0.0 ± 1.3 vs 1.3 ± 0.4 p<0.03). Interestingly, this group showed a significantly lower level of CSF-hypocretin (hrct-1) at diagnosis compared to others. A diagnosis of CPP was made in 19.6% of patients. ![]() At first evaluation, obesity was found in 31.3% of patients, while overweight was found in 25.0%. Results: Our study confirms an increased frequency of CPP and obesity in patients with NT1. The design of our study is cross-sectional at the time of diagnosis followed by a longitudinal follow-up. Methods: We retrospectively evaluated the auxological, biochemical, and radiological parameters of 112 patients referred to our Center between 2004-2022. The primary aim of this study is the evaluation of endocrine and auxological parameters at diagnosis and during follow-up in patients with NT1, treated with Sodium Oxybate (SO) or not. NT1 could be associated with endocrine comorbidities involving the neuroendocrine axis, predominantly obesity, and Central Precocious Puberty (CPP). Introduction: Narcolepsy Type 1 (NT1) is a rare hypersomnia of central origin linked to hypocretin deficiency, most frequently arising at pediatric age. 7Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio-Emilia, Modena, Italy.6Department of Medical and Surgical Sciences, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), University of Bologna, Bologna, Italy.5Pediatric Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.4Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.3Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.2Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.1Specialty School of Pediatrics, Alma Mater Studiorum, University of Bologna, Bologna, Italy.Sara Casale 1, Valentina Assirelli 1, Fabio Pizza 2,3, Antonio Balsamo 4, Monia Gennari 5, Andrea Pession 5,6, Giuseppe Plazzi 3,7 and Alessandra Cassio 5,6*
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